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Miconazole Nitrate Microsponge For Topical Drug Delivery System

Design and Evaluation of Miconazole Nitrate Microsponge for Topical Drug Delivery System-a Novel Approach for NDDS
沿って Birju Savaliya - により販売されています Dodax EU
コンディション: 新品
¥6,926
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Birju Savaliya Miconazole Nitrate Microsponge For Topical Drug Delivery System
Birju Savaliya - Miconazole Nitrate Microsponge For Topical Drug Delivery System

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配達: 2020-12-07 ~ 2020-12-09 の間
販売と配送: Dodax EU

詳細

The aim of study was to Design and Evaluation of Miconazole Nitrate Microsponge for Sustained Release Topical Drug Delivery System by Quasi-Emulsion Solvent diffusion Method. The average size of microsponge formulation is less than 300µm. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability & solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, PVA as an emulsifying agent, TEC as a plasticizer, DCM and methanol used as solvent. Optimization of Microsponge was done by using Central Composite Design.The optimized batch of Miconazole Nitrate loaded microsponge was evaluated by Particles size, shape and internal structure by SEM. Compatibility was evaluated by FTIR of optimized batch. In vitro dissolution study of miconazole nitrate microsponge confirmed that it gives sustained release effect up to 12 hour. Kinetic models of formulation confirmed that, it follows zero order kinetic. The optimized batch of microsponge was incorporated in to carbopol 934 gel, and it showed desired drug content, in vitro diffusion, spreadability, pH and viscosity as per standard criteria.

共演者・アシスタント

著者 Birju Savaliya

著者 Rajeshree Kavar

著者 Nimish Talaviya

商品詳細

DUIN 2441EQ3MJ7K

GTIN 9783846593363

言語 英語

ページ数 148

Product type 文庫本

寸法 220 x 150  mm

¥6,926
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